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Silver Solution with NanoSilver Technology

Widely used for personal healthcare, biomedical applications, including diagnoses, treatment, drug delivery, and medical device coating.

Safety Studies

Assessing orally bioavailable commercial silver nanoparticle product on human cytochrome P450 enzyme activity

Nanotechnology produces a wide range of medicinal compounds, including nanoparticulate silver, which are increasingly introduced in various forms for consumer use. As with all medicinal compounds, potential drug interactions are an important consideration for ingested silver nanoparticles. Nanoparticulate silver–drug interactions may be mediated through induced oxidative stress in liver tissue where the majority of systemically bioavailable silver nanoparticles is found. To investigate whether an orally ingested commercially available

colloidal silver nanoproduct produces pharmacokinetic interference on select cytochrome P450 enzymes, a prospective, single-blind, controlled in vivo human study using simultaneous administration of standardized probes for P450 enzyme classes CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 was conducted. Oral ingestion of a commercial colloidal silver nanoproduct produces detectable silver in human serum after 14 days of dosing. This silver, however, elicits no demonstrable clinically significant changes in metabolic, hematologic, urinary, physical findings or cytochrome P450 enzyme inhibition or induction activity. Given their increasingly broad, diverse human exposures, future characterization of human cytochrome P450 enzyme activity for other systemically bioavailable nanotechnology products are warranted.

SEE FULL STUDY       P450 Drug Interaction Table

Assessment of orally dosed commercial silver nanoparticles on human ex vivo platelet aggregation

Abstract enhanced in vitro human and ex vivo rat platelet aggregation from direct exposure to silver nanoparticles is previously reported. Given the increasing human use of engineered silver nano scale products, platelet prompted by silver nanoparticles may contribute to human cardiovascular event. To understand how direct washed platelet exposure to silver nanoparticles translates to ex vivo platelet aggregation, the authors conducted a placebo-controlled, single-blind, dose-monitored, cross-over study design in 18 healthy human coluteers. After 2 weeks of daily oral silver nanoparticle ingestion, platelet aggregation was evaluated by light transmission aggregometry diluent oral dosing. Final percent aggregation (PA) and the exchages in PA were determined using a paired design. Enhanced ex vivo platelet activation was not detectable at peak serum silver concentrations < 10 g/L. Further studies of colloidal silver nanoparticles on human platelet activities are warranted SEE FULL STUDY

First Ever Double-Blind Human-Investigation Study on Nano Silver

In vivo human time-exposure study of orally dosed commercial silver nano particles

Human biodistribution, bioprocessing and possible toxicity of nanoscale silver receive increasing health assessment. We prospectively studied commercial 10- and  32-pp, nanoscale silver particle solutions in a single-blind, controlled, cross-over, intent-to-treat, design. Healthy subjects(n=60) underwent metabolic, blood counts, urinalysis, sputum induction, and chest and abdomen magnetic resonance imaging. Silver serum and urine content were determined. No clinically important changes in metabolic, hematologic, or urinalysis measures were identified. No morphological changes were detected in the lungs, heart or abdominal orgasn. No significant changes were noted in pulmonary reactive oxygen species or pro-inflamatory cytokine generation. Invivo oral exposure to these commercial nanoscale silver particle solutions does not prompt clinically important  changes in human metabolic, hmatologic, urine, physical findings or imaging morphology. Further study of increasing syustems are warranted to assert human toxicity treshholds SEE FULL STUDY

In Vivo Human Time-Exposure Investigation of a Commercial Silver Nano­‐Particle Solution. M. A.

In-vivo oral exposure of a commercial 10 -ppm silver nano -particle  solution over 3 -, 7 -, and 14 -day exposures does not exhibit clinically important  changes in metabolic, hematologic, urine, vital sign changes, physical findings or  imaging changes visualized by MRI. Further study of increasing time -exposure, dose, and additional organ systems, including cytochrome P -450 enzymes, is warranted. SEE FULL STUDY

Nano-Silver Proven Safe

A great deal of misinformation has been released from the media claiming that nano-silver products have not been tested for safety, and that it is unknown what effects the products may have on people or the environment. It has also been stated that these silver products can cause heavy-metal poisoning. Little, if any, of this attack on nano-silver has validity, and more importantly it is the work of people or special interest groups that have something else to gain by limiting a person’s free right to have and use safe silver products. Our parent company ABL has spent millions of dollars on testing the safety and efficacy of nano-silver technology products.Read more

Nano Silver Products Safety Studies

Seven different nano silver product safety studies. Open PDF

The Safe and Non-Toxic Nature of SilverSol Technology® Products

American Biotech Labs® (ABL) SilverSol Technology® is a newly patented (#7135195) technology that is EPA approved and FDA approved. It is produced and sold as a liquid or gel. Hundreds of scientific studies have been reported to document the benefits and safe use in animals and humans. The purpose of this article is to review scientific studies, which experimentally test the safety of SilverSol. Results of this scientific review demonstrate the safety of American Biotech Labs SilverSol Technology® and identify it as a unique entity proven to be safe.Read more

VIRIDIS BioPharma – Selective Inaction of ASAP on Probiotics

Since the publication of "Science Digest" March 1978 issue reporting colloidal Silver in the article "Our Mightiest Germ Fighter"  silver is emerging as a wonder of modem medicine. Science has traveled a long way in recognizing the fact that an antibiotic kills perhaps a half-dozen different disease organism , but silver kills some 650. Also resistent strains fail to develop against silver. Moreover, silver is virtually nontoxic to humans. Obviously the question that would came to mind is how to deliver such colloidal silver internally. A standard dose of 10 ppm to 40 ppm aqueous colloidal silver is normally two spoons (-1 Oml) at a time. 1hls brings up the question as to the fate of colloidal'silver in the digestive systems as it travels through various zones of digestive system. It may undergo convertion in the acidic .., condition of the stomach. It is absorbed in the duodenum. The remaining silver as it travels further  inevitably contacts intestinal flora. SEE FULL STUDY

Anti Bacterial

120 Years of Nanosilver History: Implications for Policy Makers

ABSTRACT:

Nanosilver is one nanomaterial that is currently under a lot of scrutiny. Much of the discussion is based on the assumption that nanosilver is something new that has not been seen until recently and that the advances in nanotechnology opened completely new application areas for silver. However, we show in this analysis that nanosilver in the form of colloidal silver has been used for more than 100 years and has been registered as a biocidal material in the United States since 1954. Fifty-three percent of the EPA-registered biocidal silver products likely contain nanosilver. Most of these nanosilver applications are silver-impregnated water filters, algicides, and antimicrobial additives that do not claim to contain nanoparticles. Many human health standards for silver are based on an analysis of argyria occurrence (discoloration of the skin, a cosmetic condition) from the 1930s and include studies that considered nanosilver materials. The environmental standards on the other hand are based on ionic silver and may need to be reevaluated based on recent findings that most silver in the environment, regardless of the original silver form, is present in the form of small clusters or nanoparticles. The implications of this analysis for policy of nanosilver is that it would be a mistake for regulators to ignore the accumulated knowledge of our scientific and regulatory heritage in a bid to declare nanosilver materials as new chemicals, with unknown properties and automatically harmful simply on the basis of a change in nomenclature to the term “nano”.Read more http://www.ncbi.nlm.nih.gov/pubmed/21218770

African Human Studies of ASAP Solution

Fifty-eight patients at three hospitals in Ghana, West Africa were treated with ASAP Solution by their attending physicians. The results were so astounding, in particular with regard to Malaria, that the government of Ghana licensed ASAP Solution as a homeopathic drug. This summary lists the specific ailments and treatment results. SEE FULL STUDY

A Unique Silver Sol With Broad Antimicrobial Properties.

This research report the antibacterial activity of a Silver Sol (ASAP Solution) and compares it with representative from five classes of antibiotics-the penicillins, macrolides, cephalosporins, flourinated quinolones, and tetracyclines. Minimum inhibitory concentrations (MBCs) of anibiotics and Silver Sol were determined for fifteen strings of pathogenic bacteria. Determination of silver particles were accomplished using electron microscopy (EM) in conjunction with photoelectron spectroscopic imaging. The Silver Sol was found to have a broad spectrum of antibacterial activity when compared the other antibiotics. With the exception of two, all of the bacterial strains tested exhibited MICs of 2.5 ppm silver or less. Silver particle sizes, measured with an electron microscope (EM) ranged from 0.45 nm to 85 nm in diameter with the average being 10.6nm. Silver particles were found in the interior of both silver treated Staphylococcus aureus (S.aureus) and Escherichia coli (E. coli) cells using the EMl no visible silver particles could be seen in any cells of the other treated strains. However, Photoelectron Spectrscopic Imaging (PSI) showed that all the treated strains of abcteria, whether or not particles were visible in the EM, contained silver. A Perkin-Elmer's Atomic Adsorption instrument was used to measure the concentration of iconic silver in each batch of 44 Silver Sols produced, and this demonstrated that the Silver Sol averaged less than four percent ionic silver, An additional test, conducted by an independent analytucal chemistry laboratory' concluded that the 22 ppm Silver Sol was "primarily metallic silver" in content. Several Studies are presented to demonstrate that metallic silver is NOT toxic-and this is certainly tru at the concentrations of silver present in any of the siks included under Silver Sol. SEE FULL STUDY

Antibacterial activity of nanosilver ions and particles.

Abstract

The antibacterial activity of nanosilver against Gram negative Escherichia coli bacteria is investigated by immobilizing nanosilver on nanostructured silica particles and closely controlling Ag content and size. These Ag/SiO(2) nanoparticles were characterized by S/TEM, EDX spectroscopy, X-ray diffraction the exposed Ag surface area was measured qualitatively by O(2) chemisorption. Furthermore, the fraction of dissolved nanosilver was determined by measuring the released (leached) Ag(+) ion concentration in aqueous suspensions of such Ag/SiO(2) particles. The antibacterial effect of Ag(+) ions was distinguished from that of nanosilver particles by monitoring the growth of E. coli populations in the presence and absence of Ag/SiO(2) particles. The antibacterial activity of nanosilver was dominated by Ag(+) ions when fine Ag nanoparticles (less than about 10 nm in average diameter) were employed that release high concentrations of Ag(+) ions. In contrast, when relatively larger Ag nanoparticles were used, the concentration of the released Ag(+) ions was lower. Then the antibacterial activity of the released Ag(+) ions and nanosilver particles was comparable.Read more

Bactericidal activity of combinations of Silver–Water Dispersion™ with 19 antibiotics against seven microbial strains.

The recent increase in the incidence of infections due to bacterial resistance to antibiotics has been recognized as an alarming problem, especially in the hospital environment with probability of cross-infection. Silver–Water Dispersion®™ solution as an antibacterial is claimed to have no bacterial resistance. Nineteen antibiotics were checked in combination with Silver–Water Dispersion™ solution against seven microbial organisms for synergism. First, minimal inhibitory concentrations were determined for the individual antibiotics and Silver–Water Dispersion™ solution individually. Those combinations of individual antibiotics with Silver–Water Dispersion™ that displayed synergism were further evaluated through the checkerboard method. Synergistic activity of Silver–Water Dispersion™ solution in combination with nineteen antibiotics was tested against seven bacterial strains, except where an organ-ism was known to be resistant to the antibiotic. Out of 96 tests, five were synergistic, 89 additive, and two antagonistic. SEE FULL STUDY

Nanosilver particles in medical applications: synthesis, performance, and toxicity

Abstract

Nanosilver particles (NSPs), are among the most attractive nanomaterials, and have been widely used in a range of biomedical applications, including diagnosis, treatment, drug delivery, medical device coating, and for personal health care. With the increasing application of NSPs in medical contexts, it is becoming necessary for a better understanding of the mechanisms of NSPs’ biological interactions and their potential toxicity. In this review, we first introduce the synthesis routes of NSPs, including physical, chemical, and biological or green synthesis. Then the unique physiochemical properties of NSPs, such as antibacterial, antifungal, antiviral, and anti-inflammatory activity, are discussed in detail. Further, some recent applications of NSPs in prevention, diagnosis, and treatment in medical fields are described. Finally, potential toxicology considerations of NSPs, both in vitro and in vivo, are also addressed.Read Article

Nature inspired novel drug design paradigm using nanosilver efficacy on multi drug resistant clinical isolates of tuberculosis

Despite discovery of the pathogen more than 100 years ago, tuberculosis (TB) continues to be a major killer disease worldwide. Currently a third of world population is infected and multiple-drug-resistant (mdr) TB registers maximum mortality by a single pathogen. Nanomedicine provides enormous opportunity for developing novel drugs. We have recently demonstrated surface-modified-lipophilic-nanosilica as drug to combat malaria and 100% lethal virus, BmNPV. Nanosilver possesses inherent antibacterial properties, but toxicity is a major concern. We hypothesized that capping with nature-inspired biomolecules, bovine serum albumin (BSA) and Poly-n-vinyl-pyrrolidone (PVP) used as blood volume extender, might insure biosafety. BSA-nano-Ag was found to be more stable than PVP-nano-Ag at physiological pH. In this first ever study on clinical isolates collected from TB endemic areas, we report, BSA-nano-Ag act as potent anti-TB drug. Further study with (human serum albumin)-nano-Ag and core-shell-nano-Ag could increase the biocompatibility of oral TB drug formulations without compromising on the efficacy of the drug. Read more (PDF)

Silver nanoparticles are broad-spectrum bactericidal and virucidal compounds

The advance in nanotechnology has enabled us to utilize particles in the size of the nanoscale. This has created new therapeutic horizons, and in the case of silver, the currently available data only reveals the surface of the potential benefits and the wide range of applications. Interactions between viral biomolecules and silver nanoparticles suggest that the use of nanosystems may contribute importantly for the enhancement of current prevention of infection and antiviral therapies. Recently, it has been suggested that silver nanoparticles (AgNPs) bind with external membrane of lipid enveloped virus to prevent the infection. Nevertheless, the interaction of AgNPs with viruses is a largely unexplored field. AgNPs has been studied particularly on HIV where it was demonstrated the mechanism of antiviral action of the nanoparticles as well as the inhibition the transmission of HIV-1 infection in human cervix organ culture. This review discusses recent advances in the understanding of the biocidal mechanisms of action of silver Nanoparticles. SEE FULL STUDY

Silver Nanoparticles Impede Biofilm Formation By Pseudomonas aeruginosa and Staphylococcus epidermidis

Biofilms are ensued due to bacteria that attach to surfaces and aggregate in a hydrated polymeric matrix. Formation of these sessile communities and their inherent resistance to anti-microbial agents are the source of many relentless and chronic bacterial infections. Such biofilms are responsible play a major role in development of ocular related infectious diseases in human namely microbial keratitis. Different approaches have been used for preventing biofilm related infections in health care settings. Many of these methods have their own demerits that include chemical based complications; emergent antibiotic resistant strains, etc. silver nanoparticles are renowned for their influential anti-microbial activity. Hence the present study over the biologically synthesized silver nanoparticles, exhibited a potential anti-biofilm activity that was tested in vitro on biofilms formed by Pseudomonas aeruginosa and Staphylococcus epidermidis during 24-h treatment. Treating these organisms with silver nanoparticles resulted in more than 95% inhibition in biofilm formation. The inhibition was known to be invariable of the species tested. As a result this study demonstrates the futuristic application of silver nanoparticles in treating microbial keratitis based on its potential anti-biofilm activity. Read more (PDF)

Silver Sol and the Successful Treatment of Hospital Acquired MRSA in Human Subjects With Serious Ongoing Infection.

The patented form of Silver Sol (US Patent # 7135195) has been shown to destroy bacteria, viruses and mold in vitro and living systems (23). Staphylococcus aureus can be completely destroyed by Silver Sol in as little as two minutes and in vitro studies show it will stay dead for 28 days (24). Rustum Roy Ph.D. reported that strains of resistant staph (MRSA) could be destroyed by the Silver Sol treatment in vitro (25). The University of Cal Berkely reports that Silver Sol can completely destroy in vitro forms of MRSA (Methicillin resistant staph aureus) and VRE (Vancomyocin resistant Enterococcus) at levels as low as 2.5 ppm in as little as 45 to 60 minutes (26). With MRSA continuing to mutate and sustain resistance to antibiotics, it is encouraging to report the findings from this study which demonstrate an all-natural opponent to this modern day plague. See Full Story

SilverSol Prevents Microorganisms from Becoming Resistant.

SilverSol was compared to several antibiotics against numerous bacterial strains to determine if SilverSol could destroy the microbes and control mutation better than antibiotics. SilverSol and the following antibiotics were tested: Oflaxacin, Tetracycline, Penicillin G, and Cefaperazone. The microbial strains tested include. S, gordonii, S. mutans, S. pyogenes, E. coli, S. pneumoniae, S. typhimurium, Enterobacter, Pseudomonas aeruginosa, S. faecalis, Shigella and Staph aureus. The broth macrodilution susceptibility test was used to determine a minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of the silver hydrosol and antibiotic concentrations. See Full Story

Synthesis of well-dispersed silver nanorods of different aspect ratios and their antimicrobial properties against Gram positive and negative bacterial strains.

Abstract

In the present contribution, we describe the synthesis of highly dispersed silver nanorods (NRs) of different aspect ratios using a chemical route. The shape and size of the synthesized NRs were characterized by Transmission Electron Microscopy (TEM) and UV-visible spectroscopy. Longitudinal and transverse absorptions bands confirm the rod type structure. The experimentally recorded UV-visible spectra of NRs solutions were fitted by using an expression of the extinction coefficient for rod like nano structures under the dipole approximation. Simulated and experimentally observed UV-visible spectra were compared to determine the aspect ratios (R) of NRs. The average values of R for NR1, NR2 and NR3 solutions are estimated to be 3.0 ± 0.1, 1.8 ± 0.1 and 1.2 ± 0.1, respectively. These values are in good agreement with those obtained by TEM micrographs. The silver NRs of known aspect ratios are used to study antimicrobial activities against B. subtilis (gram positive) and E. coli (gram negative) microbes. We observed that the NRs of intermediate aspect ratio (R = 1.8) have greater antimicrobial effect against both, B. subtilis (gram positive) and E. coli (gram negative). The NRs of aspect ratio, R = 3.0 has better antimicrobial activities against gram positive than on the gram negative.Read more

Ultradilute Ag-aquasols with extraordinary bactericidal properties: role of the system Ag–O–H2O

Early in 2007, a group of eight of the world's foremost medical material scientists published this peer reviewed study. The work covered over five years of research, conducted at several international university laboratories and independent research labs. Six major commercial colloidal silvers were involved in the study, but early on the distinctive characteristics of the ASAP Solutions captured the focus of the researchers. The initial findings of this study were used as the basis for the US Patent approval, issued on 11-14-2006, providing American Biotech Labs the first ever patent protection for a unique silver particle. It was their third US Patent approval to date. The mission statement was defined thusly: We first establish the literature on the use of ultradilute aquasols as extraordinary, powerful, bactericidal inorganic agents equal to most commercial antibiotics. These findings provide the rationale for a major role for inorganic materials scientists to contribute the insights unique to their field for new, safer health vectors. Below are extracts from the paper relative to the American Biotech Labs silver sol samples used: "We examined some half a dozen commercially available 'silver colloid' products from various manufacturers, but we spent considerably more time and attention on the product of a new manufacturer (American Biotech Laboratories). This product was made by the extraordinary process of using very high voltage [...]" "We chose reliable commercial products which had demonstrated outstanding and powerful antibiotic effects in easily reproduced in vitro experiments." "The very potent biologically active silver aquasols contained, typically, the amounts of silver claimed by the manufacturer, typically from 10 to 30 ppm by weight of Ag. The silver was very pure as was the water." "The existence of these latter 'mobile', 5 nm, metallic, silver-containing units with some kind of oxide 'layers' or 'skins' around them may be a very significant finding in looking for the cause of the bio-activity." Read more

VENEREAL DISEASES: Their Treatment and cure

THE present war is doubtle responsible for the upheaval of public opinion, the awakening of the public mind to the prevalence of venereal diseases in such alarming proportions. Certainly such awakening is responsible for the recent act passed by the Ontario Legislature for combatting venereal diseases. For years we have watched with interest the abortive efforts made in various parts of'the world to grapple with this problem, and to Ontario is due the credit of instituting a unique piece of legislation (not perfect by any mean) which properly enforced, and loyally supported by the medical profession, promises results heretofore unobtble. Read more (PDF)

Anti fungal

Antifungal Effects of Silver Nanoparticle alone and with Combination of Antifungal Drug on Dermatophyte Pathogen Trichophyton Rubrum

Nano science has been emerged as a powerful tool to develop new approaches in the field of designing new antimicrobial drugs. Antimicrobial effect of silver Nano particles (Ag-NPs) were investigated on many bacteria and yeast, but there is no information about their role on dermatophyte fungi. Trichophyton rubrum is the most common agent of superficial mycoses world wide, and major causative agent for onychomycosis and tinea pedis. The aim of this study is to investigate the effect of Ag-NPs alone and in combination with fluconazole and geriseofulvin on dermatophyte pathogen. Read more (PDF)

Antifungal activity and mode of action of silver nano particles on candida albicans.

In this study, the antifungal effects of silver nano-particles (nano-Ag) and their mode of action were investigated. Nano-Ag showed antifungal effects on fungi tested with low hemolytic effects against human erythrocytes. Read more (PDF)

Antifungal Effect of Silver Nanoparticles on Dermatophytes

Spherical silver nanoparticles (nano-Ag) were synthesized and their antifungal effects on fungal pathogens of the skin were investigated. Nano-Ag showed potent activity against clinical isolates and ATCC strains of Trichophyton mentagrophytes and Candida species (IC80, 1-7 μg/ml). The activity of nano-Ag was comparable to that of amphotericin B, but superior to that of fluconazole (amphotericin B IC80, 1-5 μg/ml; fluconazole IC80, 10- 30 μg/ml). Additionally, we investigated their effects on the dimorphism of Candida albicans. The results showed nano-Ag exerted activity on the mycelia. Thus, the present study indicates nano-Ag may have considerable antifungal activity, deserving further investigation for clinical applications. Read more (PDF)

Nanosilver particles in medical applications: synthesis, performance, and toxicity

Abstract

Nanosilver particles (NSPs), are among the most attractive nanomaterials, and have been widely used in a range of biomedical applications, including diagnosis, treatment, drug delivery, medical device coating, and for personal health care. With the increasing application of NSPs in medical contexts, it is becoming necessary for a better understanding of the mechanisms of NSPs’ biological interactions and their potential toxicity. In this review, we first introduce the synthesis routes of NSPs, including physical, chemical, and biological or green synthesis. Then the unique physiochemical properties of NSPs, such as antibacterial, antifungal, antiviral, and anti-inflammatory activity, are discussed in detail. Further, some recent applications of NSPs in prevention, diagnosis, and treatment in medical fields are described. Finally, potential toxicology considerations of NSPs, both in vitro and in vivo, are also addressed.Read Article

The Silver Nanoparticle (Nano-Ag): a New Model for Antifungal Agents

In recent years, a rapid increase in microbes that are resistant to conventional antibiotics has been observed (Goffeau, 2008). Especially, the frequency of infections provoked by opportunistic fungal strains has increased dramatically. Even though the majority of invasive fungal infections are still due to the Aspergillus or Candida species, the spectrum of fungal pathogens has changed and diversified (Denning, 1991; Ellis et al., 2000; Odds et al., 2003). Azoles that inhibit sterol formation and polyenes that bind to mature membrane sterols have been the mainstays regarding antifungal therapy for several decades (Kullberg & de Pauw, 1999; Sheehan et al., 1999). However, not only the emergence of fluconazole resistance among different pathogenic strains but also the high toxicity of amphotericin B (Alexander & Perfect, 1997; Mukherjee et al., 2003) has prompted research on new antifungal agents (Kontoyiannis et al., 2003). Read more (PDF)

Antiviral

Avian Influenza A (H5N1) Virus Infection in Mice

Avian Influenza (H5N1, or Bird Flu) can be a fatal disease in humans and a serious threat to become a pandemic event. Since there is no pharmaceutical remedy for the Bird Flu it is essential that preventive treatments be tested and developed in order to enhance survivor rates in the human population. Read more

Defense Threat Reduction Agency silver nanoparticles neutralize hemorrhagic fever viruses

Department of Defense (DOD) and Defense Threat Reduction Agency (DTRA) 2009  funded study finds silver nanoparticle neutralization of hemorrhagic fever viruses including Ebola, Marburg, South american HFV and Lassa Fever. Read more (PDF)

Nanosilver particles in medical applications: synthesis, performance, and toxicity

Abstract

Nanosilver particles (NSPs), are among the most attractive nanomaterials, and have been widely used in a range of biomedical applications, including diagnosis, treatment, drug delivery, medical device coating, and for personal health care. With the increasing application of NSPs in medical contexts, it is becoming necessary for a better understanding of the mechanisms of NSPs’ biological interactions and their potential toxicity. In this review, we first introduce the synthesis routes of NSPs, including physical, chemical, and biological or green synthesis. Then the unique physiochemical properties of NSPs, such as antibacterial, antifungal, antiviral, and anti-inflammatory activity, are discussed in detail. Further, some recent applications of NSPs in prevention, diagnosis, and treatment in medical fields are described. Finally, potential toxicology considerations of NSPs, both in vitro and in vivo, are also addressed.Read Article

Silver Nanoparticles as Potential Antiviral Agents

Abstract

Virus infections pose significant global health challenges, especially in view of the fact that the emergence of resistant viral strains and the adverse side effects associated with prolonged use continue to slow down the application of effective antiviral therapies. This makes imperative the need for the development of safe and potent alternatives to conventional antiviral drugs. In the present scenario, nanoscale materials have emerged as novel antiviral agents for the possibilities offered by their unique chemical and physical properties. Silver nanoparticles have mainly been studied for their antimicrobial potential against bacteria, but have also proven to be active against several types of viruses including human imunodeficiency virus, hepatitis B virus, herpes simplex virus, respiratory syncytial virus, and monkey pox virus. The use of metal nanoparticles provides an interesting opportunity for novel antiviral therapies. Since metals may attack a broad range of targets in the virus there is a lower possibility to develop resistance as compared to conventional antivirals. The present review focuses on the development of methods for the production of silver nanoparticles and on their use as antiviral therapeutics against pathogenic viruses.Read more

Silver nanoparticles are broad-spectrum bactericidal and virucidal compounds

The advance in nanotechnology has enabled us to utilize particles in the size of the nanoscale. This has created new therapeutic horizons, and in the case of silver, the currently available data only reveals the surface of the potential benefits and the wide range of applications. Interactions between viral biomolecules and silver nanoparticles suggest that the use of nanosystems may contribute importantly for the enhancement of current prevention of infection and antiviral therapies. Recently, it has been suggested that silver nanoparticles (AgNPs) bind with external membrane of lipid enveloped virus to prevent the infection. Nevertheless, the interaction of AgNPs with viruses is a largely unexplored field. AgNPs has been studied particularly on HIV where it was demonstrated the mechanism of antiviral action of the nanoparticles as well as the inhibition the transmission of HIV-1 infection in human cervix organ culture. This review discusses recent advances in the understanding of the biocidal mechanisms of action of silver Nanoparticles. SEE FULL STUDY

Silver Sol Malaria The Indian Practitioner

Malaria afflicts half the world's population, kills more than half the children in sub-Saharan African countries, is caused by a parasite, transferred by mosquitoes, and destroys family and economic futures. Fifty-six human subjects from four separate study groups were used to determine the most effectivedose, average time to full recovery and percent of patients cured in human subjects swallowing Silver Sol. Silver Sol Liquid 10 ppm was used in different oral doses (5 ml-Lfi ml) to determine the most effective dose. SEE FULL STUDY

Swine Flu Influenza Type A/H1N1 Protection for Health Care Practitioners and Their Patients

Influenza viruses are the respiratory viruses of greatest public health importance, particularly Influenza A (1). Every year 36,000 people die from Influenza making it the 6th leading cause of death in America (1). The CDC estimates that it would cost America $71 – 166 billion if we have an Influenza epidemic today. Approximately 1 in every 1,000 swine flu patients dies from the infection. This is close to the same rate we have been seeing the past few years but antigenic drift and antigenic shift may create a new and fatal form of Influenza that humans have no immunity against (2). Antigenic drift is a variation within the HN sub-type. Read more

VENEREAL DISEASES: Their Treatment and cure

THE present war is doubtle responsible for the upheaval of public opinion, the awakening of the public mind to the prevalence of venereal diseases in such alarming proportions. Certainly such awakening is responsible for the recent act passed by the Ontario Legislature for combatting venereal diseases. For years we have watched with interest the abortive efforts made in various parts of'the world to grapple with this problem, and to Ontario is due the credit of instituting a unique piece of legislation (not perfect by any mean) which properly enforced, and loyally supported by the medical profession, promises results heretofore unobtble. Read more (PDF)

Anti inflammatory

Nanosilver particles in medical applications: synthesis, performance, and toxicity

Abstract

Nanosilver particles (NSPs), are among the most attractive nanomaterials, and have been widely used in a range of biomedical applications, including diagnosis, treatment, drug delivery, medical device coating, and for personal health care. With the increasing application of NSPs in medical contexts, it is becoming necessary for a better understanding of the mechanisms of NSPs’ biological interactions and their potential toxicity. In this review, we first introduce the synthesis routes of NSPs, including physical, chemical, and biological or green synthesis. Then the unique physiochemical properties of NSPs, such as antibacterial, antifungal, antiviral, and anti-inflammatory activity, are discussed in detail. Further, some recent applications of NSPs in prevention, diagnosis, and treatment in medical fields are described. Finally, potential toxicology considerations of NSPs, both in vitro and in vivo, are also addressed.Read Article

The Argyria Information

Chemistry behind the ‘blue man’ unlocked

Scientists have put forward a detailed biochemical model to explain argyria, a condition which turns sufferers' skin a distressing blue colour. It is caused by chronic exposure to silver and although the new work won't lead to a cure it does provide new insights into the health risks associated with silver nanoparticles that are now ubiquitous in modern life. SEE FULL STUDY or Watch Video

Using Silver Solutions and The Risk of Argyria

Humanity has had a love affair with silver for thousands of years. Historically the precious metal was used in medicine, eating utensils, plates, cups, food containers, jewelry, money/coins, clothes, building materials, and as a disinfectant for water and human infection. Silver has historically touched almost every facet of life for those who could afford it. Now, after hundreds of years of study and significant gains in knowledge, science and technology, silver is still used for medicine, eating utensils, plates, cups, food containers, jewelry, money/coins, clothes, building materials, and as a disinfectant. SEE FULL STUDY

The Structure Of Liquid Water

The Structure Of Liquid Water

One must begin by distinguishing the different uses of the term “structure of water” as used by materials scientists, from that used by chemists. The authors present the materials science perspective because they are interested only in the condensed liquid phase. Essentially all previous literature on the structure of water has been dominated by chemists who equate the term “structure” with the identification of the molecular species present in the water as vapor or as liquid, at its surface, or in some specific environment. Several dozens of such molecular species have been identified, calculated or inferred: i.e. the size and shape of the building blocks of this condensed matter are known. What is very little known, is the materials scientist’s approach to the structure of condensed matter: i.e. the arrangement of these building blocks in 3-D space. The authors systematically bring various well-known principles and phenomena from materials research to bear on the topic. Read more

What is Nano Silver

NANO SILVER

What is Nano Silver?
Through years of testing, our manufacturing team successfully developed and patented a manufacturing process that created a much more stable silver product. This new silver technology created an engineered silver nano particle; making it the best silver product ever created. This new nano silver technology is far superior to the older process, known as colloidal silver. With both manufacturing processes, the silver particle is inside a water molecule. The older process creates larger particles with jagged edges, which cause the particles to break through the water molecule. When a particle breaks through, it can attach itself to tissues inside the human body. Over time, using colloidal silvers can cause a buildup of particles and may become toxic, similar to taking too much Iron and other minerals. This is not the case with the new patented process used with One Silver Solution. The particles are engineered down to nano sized particles with a thin multivalent silver oxide coating and do not break through the water molecule. This allows the particles to travel more efficiently through the body and will be flushed out within approximately forty-eight hours.
Read more

Nano Silver Explained

Nano-Silver is pure de-ionized water with silver (Ag) in suspension. Approximately 80% of the silver is in the form of metallic silver nano-particles. The remaining silver is in ionic form. Though similar to colloidal silver, generally, a colloid is a suspension of particles of from 10 nm to 1 micron in diameter and the silver particles in Nano-Silver are less than 2 nm in diameter and therefore too small to be considered in "colloidal" suspension. They are rather, in a "nano-suspension," a much more stable state. Read more

What is the difference?

Particle Size, And Ionic Vs. Metallic Silver Products

Much ado has been made about particle size in the effectiveness of silver products. There is a great deal of misinformation circulating the web about nano silver products, including those products manufactured by American Biotech Labs (ABL). Because ABL has invested millions of dollars in testing and research, and has independent data from numerous universities and private institutions, it has information that no other company has access to. This study and test information can defray some of the misinformation that resounds on this subject. Read more

 

Silver Sol and Colloidal Silver: What's the Difference?

Not all silver is created equal. Silver sol and colloidal silver are wildly different things. 

Many people who are new to using silver for health may think that all silver products are the same, but there are some stark differences. The two main forms of silver are colloidal silver and silver sol, but which one is the best choice for you? Our experts have come up with this guide to help you learn the differences between colloidal silver and silver sol:

1) Suspensions and Solutions

Colloidal silver is a suspension and silver sol is a solution. The biggest difference between a solution and suspension is the size of the silver particles. Suspensions have larger particles, and while they aren't large enough to be seen, given enough time, they are still large enough to start settling at the bottom of the container. The particles in a solution are very small, so small in fact that they won't sink to the bottom of the container.

2) Safety

While colloidal silver can contain impurities, silver solution is lab tested to be safe. The particles in colloidal silver are also jagged and can break through water molecules and attach themselves within your body. Over time, those particles can start to build up and lead to a condition called Argyria. Because our products are made using nano silver technology, they have a silver oxide coding that prevents them from breaking through the water molecule.

3) Bioavailability

Bioavailability is the proportion of any given supplement or drug that actually enters into circulation in the body and has an active effect.  The bioavailability of colloidal silver is anywhere from 15-65% (depending on the manufacturer), whereas the bioavailability of silver solution exceeds 99%!

4) Color, Odor and Taste

Colloidal silver is generally silver, yellow or brown in color, while silver solution is colorless. Colloidal silver has a distinct metallic flavor, while silver solution has a very faint metallic aftertaste. Colloidal silver also has a strong odor, whereas silver solution is odorless.

5) Missing Electrons

Colloidal silver and silver sol work the same way, they each have a missing electron. The silver destroys bacteria by removing electrons from it. Colloidal silver is missing a single electron while silver sol is missing 2. This allows silver sol to destroy one electron and charge another at the same time; in other words, silver sol is constantly killing bacteria and recharging all at once, making it much more powerful than colloidal silver.

As you can see, colloidal silver and silver sol are wildly different things, and there are many wonderful benefits to choosing silver sol. Learn more when you visit us online today.

Wound healing

Arm and Hand Wound Case Study

The subject’s wound was from surgery and was managed under the supervision of a physician. Armor Gel was applied topically to the wound, and it was covered with a bandage. The Armor Gel was then reapplied every time the bandage or brace was removed to do therapy (5 times daily). No other wound management products were used. Read more (PDF)

A Clinical Review of the Treatment of Diabetic Ulcers, Pressure Ulcers and Venous Stasis Ulcers in Human Subjects Using Silver Sol Gel While Residing in a Geriatric Health Care Facility

Diabetic ulcers, pressure ulcers and venous stasis ulcers were treated with Silver Sol Gel in conjunction with Advanced Healing Systems Formulary process that includes new technologies that are in combination with the best practices available in wound care resulting in remarkable recoveries. The weekly photographic and empirical quantification of the healing processes are recorded in this study. The weekly improvements seen in very difficult cases illustrate the broad-spectrum abilities of Silver Sol Gel. Diabetics suffer from hormone changes, reduced blood flow to extremities and wounds that heal very slowly if at all. These diabetic wounds remain open for long periods of time and are susceptible to bacterial, viral and fungal infection. Diabetic wounds have been shown to be polymicrobial and difficult to treat. See Full Story

A Novel New Nanoparticle Silver Hydrogel* on Surgical Sites - A Case Series

Over the years there have been many opportunities to address surgical site contamination and post-operative infections in the outpatient setting. Most notably, since the advent of Methicillin-resistant infections and an increasing diabetic patient population (this also includes pre-diabetic patients), the risks for surgery have increased in the ability of a patient to properly heal, even with primary intention closure. For centuries, human beings have utilized silver-based dressings and silver itself as a method of battling contaminant bacteria and viruses. In today’s modern age of medicine, the use of nanometric silver products has become mainstream. SEE FULL STUDY

Silver Sol and the Successful Treatment of Hospital Acquired MRSA in Human Subjects With Serious Ongoing Infection.

The patented form of Silver Sol (US Patent # 7135195) has been shown to destroy bacteria, viruses and mold in vitro and living systems (23). Staphylococcus aureus can be completely destroyed by Silver Sol in as little as two minutes and in vitro studies show it will stay dead for 28 days (24). Rustum Roy Ph.D. reported that strains of resistant staph (MRSA) could be destroyed by the Silver Sol treatment in vitro (25). The University of Cal Berkely reports that Silver Sol can completely destroy in vitro forms of MRSA (Methicillin resistant staph aureus) and VRE (Vancomyocin resistant Enterococcus) at levels as low as 2.5 ppm in as little as 45 to 60 minutes (26). With MRSA continuing to mutate and sustain resistance to antibiotics, it is encouraging to report the findings from this study which demonstrate an all-natural opponent to this modern day plague. See Full Story

Other Medical Uses

Antitumor activity of silver nanoparticles in Dalton’s lymphoma ascites tumor model

Abstract

Nanomedicine concerns the use of precision-engineered nanomaterials to develop novel therapeutic and diagnostic modalities for human use. The present study demonstrates the efficacy of biologically synthesized silver nanoparticles (AgNPs) as an antitumor agent using Dalton’s lymphoma ascites (DLA) cell lines in vitro and in vivo. The AgNPs showed dose- dependent cytotoxicity against DLA cells through activation of the caspase 3 enzyme, leading to induction of apoptosis which was further confirmed through resulting nuclear fragmentation. Acute toxicity, ie, convulsions, hyperactivity and chronic toxicity such as increased body weight and abnormal hematologic parameters did not occur. AgNPs significantly increased the survival time in the tumor mouse model by about 50% in comparison with tumor controls. AgNPs also decreased the volume of ascitic fluid in tumor-bearing mice by 65%, thereby returning body weight to normal. Elevated white blood cell and platelet counts in ascitic fluid from the tumor-bearing mice were brought to near-normal range. Histopathologic analysis of ascitic fluid showed a reduction in DLA cell count in tumor-bearing mice treated with AgNPs. These findings confirm the antitumor properties of AgNPs, and suggest that they may be a cost-effective alternative in the treatment of cancer and angiogenesis-related disorders. SEE FULL STUDY

Bactericidal activity of combinations of Silver–Water Dispersion™ with 19 antibiotics against seven microbial strains.

The recent increase in the incidence of infections due to bacterial resistance to antibiotics has been recognized as an alarming problem, especially in the hospital environment with probability of cross-infection. Silver–Water Dispersion®™ solution as an antibacterial is claimed to have no bacterial resistance. Nineteen antibiotics were checked in combination with Silver–Water Dispersion™ solution against seven microbial organisms for synergism. First, minimal inhibitory concentrations were determined for the individual antibiotics and Silver–Water Dispersion™ solution individually. Those combinations of individual antibiotics with Silver–Water Dispersion™ that displayed synergism were further evaluated through the checkerboard method. Synergistic activity of Silver–Water Dispersion™ solution in combination with nineteen antibiotics was tested against seven bacterial strains, except where an organ-ism was known to be resistant to the antibiotic. Out of 96 tests, five were synergistic, 89 additive, and two antagonistic. SEE FULL STUDY

Colloidal Nano Silver-Its Production Method, Properties, Standards and its Bio-efficacy as an Inorganic Antibiotic

he past 80 years has seen a plethora of different methods used to produce pretend colloidal silver that more often than not, consists mainly of ionic silver and other chemicals. Generally, little or no colloidal material is seen. Normally, only a ratio of Ionic to Colloidal Silver of 85:15% is quoted as the best obtainable result. Colloidal silver generally consists of nano sized clusters of silver atoms in an aqueous solution. We should not refer to them as particles. These atomic clusters are of a neutral polarity, but their suspension in the water causes a highly negative (interfacial) electrostatic charge called the Zeta potential. It is this highly negative Zeta potential of the clusters that causes a mutual repelling action resulting in an almost permanent suspension. This interfacial electrical charge is vulnerable to high temperatures and contamination by ionic substances. Even small amounts of ionic silver can  interfere with this normal repelling action. Any of these contaminations may cause a drop in the interfacial charge causing aggregation and the release of attraction forces, such as the Van der Waals force, present in all materials. What follows is an uncontrolled growth of ever larger clusters to a point where gravity takes over and metallic silver drops out of the suspension. It has been determined that Colloidal Silver clusters should not be referred to as metallic, as at 10 nm size and below, they do not behave like a metal or controlled by standard physical laws. Because of this, nano sized silver clusters exhibit characteristics that are not present in bulk metallic silver. Some of these characteristics of nano sized colloidal silver can only be explained as being quantum phenomena. In this paper, we will show by using only the purest water and silver commercially available (99.998%), and by precisely controlling temperature, light and electrical conditions, and stable high grade, colloidal silver can be consistently produced using electrochemical principles. Some of our material has shown little signs of deterioration over many years. By also controlling the actual atomic cluster to a narrow size distribution and concentration, a highly effective antibacterial substance is created. That blue, indigo, violet and UV light plays such a most crucial role in the formation of colloidal silver has only recently been recognised by some scientists. It is ironic to realise that knowledge of the capabilities of short wavelength electromagnetic radiation, over and above 2.64 electron volt (eV), has been known for decades, even for nature and life itself. Few, if any, have paid any attention to the significance of these short wavelengths of light on colloidal silver production. One example of this is the role of UV on the skin promoting the production of Vitamin D. Similarly, UV exposure on silver halide deposited on B&W film produces a latent (photographic) image. In this paper, we will illustrate that blue, indigo, violet light, and in particular, where light has the greatest penetration of water and light is absorbed by silver, i.e. 418 nm, pure colloidal silver can be produced most efficiently. SEE FULL STUDY

Effect of Prophylactic Treatment with ASAP-AGX-32 and ASAP Solutions on an Avian Influenza A (H5N1) Virus Infection in Mice

Avian Influenza (H5N1, or Bird Flu) can be a fatal disease in humans and a serious threat to become a pandemic event. Since there is no pharmaceutical remedy for the Bird Flu it is essential that preventive treatments be tested and developed in order to enhance survivor rates in the human population. Since 1973, Silver has been shown to have topical activity against 22 bacterial species (643 isolates) including gram positive and gram negative bacteria (1). As an antimicrobial agent, Silver has been shown to be beneficial in the treatment and prevention
of burn infections, post surgical wound infections, and gynecological infections (2, 3). In addition, Silver has been shown to be active against black mold (4), Antrax (5), Bubonic plague (6), Malaria (7), and numerous viruses such as Hepatitis (8). Recently it was reported that the American Biotech Labs product, Silver Sol, demonstrated additive and synergistic effects when combined in individual trials with 19 different antibiotics (9). The Silver from
ABL was shown to improve the effectiveness of the antibiotics even against antibiotic resistant infections
(9).
SEE FULL STUDY

First Ever Double-Blind Human-Investigation Study on Nano Silver

In vivo human time-exposure study of orally dosed commercial silver nano particles

Human biodistribution, bioprocessing and possible toxicity of nanoscale silver receive increasing health assessment. We prospectively studied commercial 10- and  32-pp, nanoscale silver particle solutions in a single-blind, controlled, cross-over, intent-to-treat, design. Healthy subjects(n=60) underwent metabolic, blood counts, urinalysis, sputum induction, and chest and abdomen magnetic resonance imaging. Silver serum and urine content were determined. No clinically important changes in metabolic, hematologic, or urinalysis measures were identified. No morphological changes were detected in the lungs, heart or abdominal orgasn. No significant changes were noted in pulmonary reactive oxygen species or pro-inflamatory cytokine generation. Invivo oral exposure to these commercial nanoscale silver particle solutions does not prompt clinically important  changes in human metabolic, hmatologic, urine, physical findings or imaging morphology. Further study of increasing syustems are warranted to assert human toxicity treshholds SEE FULL STUDY

Silver nano — A trove for retinal therapies

Pathological retinal angiogenesis (neovascularization) is one of the most feared complications among retinal diseases, leading to visual impairment and irreversible blindness. Recent findings made by us on therapeutic applications of biologically synthesized silver nanoparticles (AgNPs) against VEGF induced retinal endothelial cells, elucidates the effectual inhibitory activities of AgNPs over the downstream signaling pathways (Src and AKT/PI3K) leading to retinal angiogenesis. The current review focuses on the imperative role of VEGF induced angiogenesis in the development of retinal neovascularization and despite the fact that several VEGF targeting ocular drugs are available; the review examines the need for a cost economic alternative, thereby suggesting the role of AgNPs as an emerging economic ocular drug for retinal therapies. The current technologies available for the development of targeted and controlled release of drugs is being discussed and a model has been proposed for the amenable targeting mechanism, by which Poly gamma glutamic acid (PGA) capsulated AgNPs conjugated to cyclic RGD peptides carry out a sustained controlled release specifically targeting the neovascularization cells and induce apoptosis unaffecting the normal retinal cells. These constructs consequently affirm the futuristic application of silver nanoparticles as a boon to ocular therapies. Read more (PDF)

Silver nanoparticles are broad-spectrum bactericidal and virucidal compounds

The advance in nanotechnology has enabled us to utilize particles in the size of the nanoscale. This has created new therapeutic horizons, and in the case of silver, the currently available data only reveals the surface of the potential benefits and the wide range of applications. Interactions between viral biomolecules and silver nanoparticles suggest that the use of nanosystems may contribute importantly for the enhancement of current prevention of infection and antiviral therapies. Recently, it has been suggested that silver nanoparticles (AgNPs) bind with external membrane of lipid enveloped virus to prevent the infection. Nevertheless, the interaction of AgNPs with viruses is a largely unexplored field. AgNPs has been studied particularly on HIV where it was demonstrated the mechanism of antiviral action of the nanoparticles as well as the inhibition the transmission of HIV-1 infection in human cervix organ culture. This review discusses recent advances in the understanding of the biocidal mechanisms of action of silver Nanoparticles. SEE FULL STUDY

Silver Nanoparticles as Potential Antiviral Agents

Virus infections pose significant global health challenges, especially in view of the fact that the emergence of resistant viral strains and the adverse side effects associated with prolonged use continue to slow down the application of effective antiviral therapies. This makes imperative the need for the development of safe and potent alternatives to conventional antiviral drugs. In the present scenario, nanoscale materials have emerged as novel antiviral agents for the possibilities offered by their unique chemical and physical properties. SEE FULL STUDY

Silver Sol Malaria The Indian Practitioner

Malaria afflicts half the world's population, kills more than half the children in sub-Saharan African countries, is caused by a parasite, transferred by mosquitoes, and destroys family and economic futures. Fifty-six human subjects from four separate study groups were used to determine the most effectivedose, average time to full recovery and percent of patients cured in human subjects swallowing Silver Sol. Silver Sol Liquid 10 ppm was used in different oral doses (5 ml-Lfi ml) to determine the most effective dose. SEE FULL STUDY

Silver Sol Improves Wound Healing: Case Studies In the Use of Silver Sol in Closing Wounds (Including MRSA), Preventing Infection, Inflammation and Activating Stem Cells

Wound healing is a complex and fragile process, which can be complicated by infection and inflammation. In this study, multiple cases are reviewed pictorially for the purpose of recording improved wound healing using the antimicrobial Silver Sol gel. The daily use of Silver Sol gel results in reduced infection (including MRSA), which leads to less inflammation. By reducing the inflammation and infection wounds close faster and with less scaring. This remarkable review of the healing process strongly suggests that Silver Sol gel helps disinfect the wound, prevents further infection, helps reduce inflammation and stimulates stem cells which results in improved wound healing characterized by reduced inflammation, improved angiogenesis, faster phagocytosis and reduced scarring. SEE FULL STUDY

The Brigham Young University Microbiology Department Study

The ASAP Silver Solution effectively killed thousands of bacterial strains that are responsible for many health related conditions. In a major university study, Sr. Ron Leavitt, head of the Molecular Biology and Microbiology department, conluded that the ASAP Silver Solution killed every strain of deadly bacteria detailed in the diagram below.  SEE FULL STUDY

Ultradilute Ag-aquasols with extraordinary bactericidal properties: role of the system Ag–O–H2O

Early in 2007, a group of eight of the world's foremost medical material scientists published this peer reviewed study. The work covered over five years of research, conducted at several international university laboratories and independent research labs. Six major commercial colloidal silvers were involved in the study, but early on the distinctive characteristics of the ASAP Solutions captured the focus of the researchers. The initial findings of this study were used as the basis for the US Patent approval, issued on 11-14-2006, providing American Biotech Labs the first ever patent protection for a unique silver particle. It was their third US Patent approval to date. The mission statement was defined thusly: We first establish the literature on the use of ultradilute aquasols as extraordinary, powerful, bactericidal inorganic agents equal to most commercial antibiotics. These findings provide the rationale for a major role for inorganic materials scientists to contribute the insights unique to their field for new, safer health vectors. Below are extracts from the paper relative to the American Biotech Labs silver sol samples used: "We examined some half a dozen commercially available 'silver colloid' products from various manufacturers, but we spent considerably more time and attention on the product of a new manufacturer (American Biotech Laboratories). This product was made by the extraordinary process of using very high voltage [...]" "We chose reliable commercial products which had demonstrated outstanding and powerful antibiotic effects in easily reproduced in vitro experiments." "The very potent biologically active silver aquasols contained, typically, the amounts of silver claimed by the manufacturer, typically from 10 to 30 ppm by weight of Ag. The silver was very pure as was the water." "The existence of these latter 'mobile', 5 nm, metallic, silver-containing units with some kind of oxide 'layers' or 'skins' around them may be a very significant finding in looking for the cause of the bio-activity." Read more

VIRIDIS BioPharma – Selective Inaction of ASAP on Probiotics

Since the publication of "Science Digest" March 1978 issue reporting colloidal Silver in the article "Our Mightiest Germ Fighter"  silver is emerging as a wonder of modem medicine. Science has traveled a long way in recognizing the fact that an antibiotic kills perhaps a half-dozen different disease organism , but silver kills some 650. Also resistent strains fail to develop against silver. Moreover, silver is virtually nontoxic to humans. Obviously the question that would came to mind is how to deliver such colloidal silver internally. A standard dose of 10 ppm to 40 ppm aqueous colloidal silver is normally two spoons (-1 Oml) at a time. 1hls brings up the question as to the fate of colloidal'silver in the digestive systems as it travels through various zones of digestive system. It may undergo convertion in the acidic .., condition of the stomach. It is absorbed in the duodenum. The remaining silver as it travels further  inevitably contacts intestinal flora. SEE FULL STUDY